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      HDL-associated lysosphingolipids inhibit NAD(P)H oxidase-dependent monocyte chemoattractant protein-1 production.

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          Abstract

          High-density lipoprotein (HDL) levels are inversely proportional to the risk of atherosclerosis, but mechanisms of HDL atheroprotection remain unclear. Monocyte chemoatractant protein-1 (MCP-1) constitutes an early component of inflammatory response in atherosclerosis. Here we investigated the influence of HDL on MCP-1 production in vascular smooth muscle cells (VSMCs) and rat aortic explants.

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          Author and article information

          Journal
          Arterioscler. Thromb. Vasc. Biol.
          Arteriosclerosis, thrombosis, and vascular biology
          Ovid Technologies (Wolters Kluwer Health)
          1524-4636
          1079-5642
          Aug 2008
          : 28
          : 8
          Affiliations
          [1 ] Charite - Campus Benjamin Franklin, Medizinische Klinik, Berlin, Germany.
          Article
          ATVBAHA.107.161042 NIHMS125980
          10.1161/ATVBAHA.107.161042
          2723752
          18483405

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