Discovery of Amantamide, a Selective CXCR7 Agonist from Marine Cyanobacteria

Abstract

CXCR7 plays an emerging role in several physiological processes. A linear peptide, amantamide ( 1 ), was isolated from marine cyanobacteria and the structure determined by NMR and mass spectrometry. The total synthesis was achieved by solid-phase method. After screening two biological target libraries, 1 was identified as a selective CXCR7 agonist. The selective activation of CXCR7 by 1 could provide the basis for developing CXCR7 targeted therapeutics and deciphering the role of CXCR7 in different diseases.