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      Signalling through phosphoinositide 3-kinases: the lipids take centre stage

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      Current Opinion in Cell Biology
      Elsevier BV

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          Abstract

          Phosphoinositide 3-kinases (PI3Ks) phosphorylate inositol lipids at the 3' position of the inositol ring to generate the 3-phosphoinositides PI(3)P, PI(3,4) P2 and PI(3,4,5) P3. Recent research has shown that one way in which these lipids function in signal transduction and membrane trafficking is by interacting with 3-phosphoinositide-binding modules in a broad variety of proteins. Specifically, certain FYVE domains bind PI(3)P whereas certain pleckstrin homology domains bind PI(3,4) P2 and/or PI(3,4,5) P3. Also in 1998, PTEN - a major tumour suppressor in human cancer - was also shown to antagonise PI3K signalling by removing the 3-phosphate from 3-phosphoinositides.

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          Author and article information

          Journal
          Current Opinion in Cell Biology
          Current Opinion in Cell Biology
          Elsevier BV
          09550674
          April 1999
          April 1999
          : 11
          : 2
          : 219-225
          Article
          10.1016/S0955-0674(99)80029-5
          10209156
          8b5c7ee0-dfa0-49e2-9bb8-bc9be9649329
          © 1999

          https://www.elsevier.com/tdm/userlicense/1.0/

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