Blog
About

10
views
0
recommends
+1 Recommend
0 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: not found

      Tracking the transformations of mesoporous microspheres of calcium silicate hydrate at the nanoscale upon ibuprofen release: a XANES and STXM study

      Read this article at

      ScienceOpenPublisher
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          XANES and STXM imaging of mesoporous CSH microspheres indicate that amorphous silica provide aggregation site of HAp, and amorphous CaCO 3 was formed during CSH biomineralization.

          Abstract

          Drug release and the accompanying biomineralization of the drug carrier, mesoporous calcium silicate hydrate (CSH) microspheres, are monitored with X-ray absorption near edge structures and scanning transmission X-ray microscopy (STXM). The in vitro biomineralization of hydroxyapatite (HAp) on CSH microspheres is investigated by tracking specimens soaked in simulated body fluid (SBF) for various time periods; the study is complemented with X-ray powder diffraction. We clarified the presence of amorphous CaCO 3 at the early stage of biomineralization with solid evidence, which is still controversial from previous studies. More importantly, the observations from the STXM images and microscopy spectra directly demonstrated that amorphous SiO 2 from the hydrolysis of silicate ions provide the preferential sites for the aggregation of HAp. These results demonstrate that XANES and STXM are sensitive techniques which can be used to analyze various bioceramics for medical applications.

          Related collections

          Most cited references 45

          • Record: found
          • Abstract: not found
          • Article: not found

          Hydrolysis and condensation of silicates: Effects on structure

           C.J. Brinker (1988)
            Bookmark
            • Record: found
            • Abstract: not found
            • Article: not found

            29Si MAS NMR study of the structure of calcium silicate hydrate

              Bookmark
              • Record: found
              • Abstract: not found
              • Article: not found

              Assignment of pre-edge peaks in K-edge x-ray absorption spectra of 3d transition metal compounds: electric dipole or quadrupole?

                Bookmark

                Author and article information

                Journal
                CRECF4
                CrystEngComm
                CrystEngComm
                Royal Society of Chemistry (RSC)
                1466-8033
                2015
                2015
                : 17
                : 22
                : 4117-4124
                Affiliations
                [1 ]Department of Chemistry
                [2 ]University of Western Ontario
                [3 ]London, Canada
                [4 ]Shanghai Institute of Ceramics
                [5 ]Chinese Academy of Sciences
                [6 ]Shanghai 200050, China
                [7 ]Canadian Light Source
                [8 ]Saskatoon, Canada
                Article
                10.1039/C5CE00500K
                © 2015
                Product
                Self URI (article page): http://xlink.rsc.org/?DOI=C5CE00500K

                Comments

                Comment on this article