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      Sequence variations in PCSK9, low LDL, and protection against coronary heart disease.

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          Abstract

          A low plasma level of low-density lipoprotein (LDL) cholesterol is associated with reduced risk of coronary heart disease (CHD), but the effect of lifelong reductions in plasma LDL cholesterol is not known. We examined the effect of DNA-sequence variations that reduce plasma levels of LDL cholesterol on the incidence of coronary events in a large population.

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          Author and article information

          Journal
          N. Engl. J. Med.
          The New England journal of medicine
          New England Journal of Medicine (NEJM/MMS)
          1533-4406
          0028-4793
          Mar 23 2006
          : 354
          : 12
          Affiliations
          [1 ] Donald W. Reynolds Cardiovascular Clinical Research Center, University of Texas Southwestern Medical Center, Dallas, TX 75390-9046, USA.
          Article
          354/12/1264
          10.1056/NEJMoa054013
          16554528

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