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Sequence variations in PCSK9, low LDL, and protection against coronary heart disease.

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      Abstract

      A low plasma level of low-density lipoprotein (LDL) cholesterol is associated with reduced risk of coronary heart disease (CHD), but the effect of lifelong reductions in plasma LDL cholesterol is not known. We examined the effect of DNA-sequence variations that reduce plasma levels of LDL cholesterol on the incidence of coronary events in a large population.

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      Affiliations
      [1 ] Donald W. Reynolds Cardiovascular Clinical Research Center, University of Texas Southwestern Medical Center, Dallas, TX 75390-9046, USA.
      Journal
      N. Engl. J. Med.
      The New England journal of medicine
      New England Journal of Medicine (NEJM/MMS)
      1533-4406
      0028-4793
      Mar 23 2006
      : 354
      : 12
      16554528 354/12/1264 10.1056/NEJMoa054013

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