Circulating Immune Complexes after Cadaver Kidney Transplantation

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Abstract

351 sera from 27 human recipients of renal allografts and 21 healthy blood donors were assayed for circulating immune complexes by the C1q solid-phase radioimmune assay. Increased C1q-binding activity (C1q-BA) was detected in pretransplant sera from 5 patients with chronic pyelonephritis (PN) and 3 patients with chronic glomerulonephritis (GN). A significant decrease of C1q-BA immediately after transplantation could not be found. 6 weeks after transplantation only 2 patients of the PN group showed increased C1q-BA. Serial studies in 17 patients with rejection crises did not show any correlation between the level of serum C1q-BA and the occurrence of rejections. Furthermore, no correlation could be found between the occurrence of complement-dependent lymphocytotoxic antibodies measured by the <sup>51</sup>Cr release technique and the level of serum C1q-BA. In contrast, our results show that the probability of graftectomy or graft failure is significantly higher, at least in the early phase after transplantation, when the serum C1q-BA is lowered for several weeks.

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Author and article information

Journal

Journal ID (publisher-id): NEF

Journal ID (nlm-ta): Nephron

Journal ID (doi): 10.1159/issn.1660-8151

Title: Nephron

Publisher: S. Karger AG

ISSN (Print): 1660-8151

ISSN (Electronic): 2235-3186

Publication date Subscription-year: 1981

Publication date (Print): 1981

Publication date (Electronic): 02 December 2008

Volume: 28

Issue: 3

Pages: 127-132

Affiliations

Städtisches Krankenhaus im Friedrichshain, Department of Urology, Chair of Urology and Division of Clinical Immunology of the Humboldt University, Berlin, GDR

Article

Publisher ID: 182133 Other ID: Nephron 1981;28:127–132

DOI: 10.1159/000182133

PubMed ID: 7029320

SO-VID: 8b782d58-63b9-495b-824c-aa519fb05c81

License:

Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

History

Date accepted : 16 September 1980

Page count

Pages: 6

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