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      Inhibition of Platelet-Activating Factor-Induced Retinal Impairments by Cholera and Pertussis Toxins


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          Platelet-activating factor (PAF) has been shown to alter the transretinal potential recorded from light-stimulated isolated retina. In the present study, we investigated the effect of cholera and pertussis toxins on PAF-induced impairment of the electroretinogram (ERG). Administered alone, 2.10<sup>––</sup><sup>7</sup> M PAF induced a very marked and rapid drop in the b-wave amplitude. When 75 μg/l of cholera toxin was coadministered with PAF in the perfusion solution, no b-wave drop was observed, suggesting that the effect of PAF on retinal function was mediated by GTP-binding protein (G protein). Similarly, a low dose of pertussis toxin (5 μg/l) was sufficient to antagonize the action of PAF on the ERG. Our results suggest that the irreversible and deleterious effect of PAF on ERG is mediated by a G protein mechanism, located in the neural retina.

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          Author and article information

          Ophthalmic Res
          Ophthalmic Research
          S. Karger AG
          11 December 2009
          : 27
          : 3
          : 153-157
          aLaboratoire de Biophysique, Facultés de Médecine et de Pharmacie, Clermont-Ferrand, France; bLSU Eye Center and Neuroscience Center, New Orleans, La., USA; cIHB Laboratoires de Recherche, Le Plessis-Robinson, France
          267654 Ophthalmic Res 1995;27:153–157
          © 1995 S. Karger AG, Basel

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          : 28 October 1994
          : 10 January 1995
          Page count
          Pages: 5
          Original Paper

          Vision sciences,Ophthalmology & Optometry,Pathology
          Platelet-activating factor,Isolated rat retina,G protein,Electroretinogram


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