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      Actions of Desmopressin and Vasopressin on the Perfused Nasal Vasculature of the Dog

      ,

      Journal of Vascular Research

      S. Karger AG

      Desmopressin, Vasopressin, Nasal vasculature, Resistance, nasal, Secretion, nasal

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          Abstract

          Desmopressin and vasopressin were injected into the blood supply of the bilaterally perfused nasal mucosa of the dog. Nasal vascular resistance and, in some experiments, nasal airflow resistance and the secretory output of the lateral nasal gland were measured on both sides. Systemic arterial blood pressure was recorded. Desmopressin caused a dose-related vasodilatation on the side of injection with no changes in systemic arterial blood pressure or secretion by the lateral nasal gland. Nasal airflow resistance did not change significantly. Vasopressin increased nasal vascular resistance on the side of injection with no changes in the systemic arterial blood pressure or secretion by the lateral nasal gland. Nasal airflow resistance did not change significantly. Thus desmopressin dilates the nasal vascular bed and vasopressin constricts it. The relevance of these findings to the use of the two agents applied in to the nose in clinical practice is discussed.

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          Author and article information

          Journal
          JVR
          J Vasc Res
          10.1159/issn.1018-1172
          Journal of Vascular Research
          S. Karger AG
          1018-1172
          1423-0135
          1994
          1994
          23 September 2008
          : 31
          : 4
          : 216-220
          Affiliations
          Department of Physiology, St. George’s Hospital Medical School, London, UK
          Article
          159046 J Vasc Res 1994;31:216–220
          10.1159/000159046
          8025181
          © 1994 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          Page count
          Pages: 5
          Categories
          Research Paper

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