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      Effects of Antihypertensive Drug Therapy on the Morphology and Mechanics of Resistance Arteries from Spontaneously Hypertensive Rats

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          Abstract

          Spontaneously hypertensive (SHR) and normotensive Wistar-Kyoto rats (WKY), 25 weeks of age, were treated for 23 weeks with hydrochlorothiazide, hydralazine, and reserpine added to their drinking water. Cylindrical segments of mesenteric arteries (about 170 µm diameter, and 0.7 mm long) were isolated and mounted in a myograph for dimensional and circumferential tension measurements. Treatment of the SHR and WKY decreased systolic blood pressures by 29% and the smooth muscle cell (SMC) content of these vessels by 31%. A linear relation was found between blood pressure and SMC content for all treated and untreated rats. Our results suggest that effect of treatment on the cellular content of the media was sufficient to account entirely for the maintenance of the lowered blood pressure.

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          Author and article information

          Journal
          JVR
          J Vasc Res
          10.1159/issn.1018-1172
          Journal of Vascular Research
          S. Karger AG
          1018-1172
          1423-0135
          1980
          1980
          19 September 2008
          : 17
          : 5
          : 257-270
          Affiliations
          Department of Physiology and Biophysics, University of Vermont, Burlington, Vt.
          Article
          158255 Blood Vessels 1980;17:257–270
          10.1159/000158255
          © 1980 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          Page count
          Pages: 14
          Categories
          Research Paper

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