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Elevated activated partial thromboplastin time during administration of first-generation adenoviral vectors for gene therapy for prostate cancer: Identification of lupus anticoagulants
Bahaa S. Malaeb ,
Thomas A. Gardner ,
Vitaly Margulis ,
Ling Yang ,
Jay Y. Gillenwater ,
Leland W.K. Chung ,
Gail Macik ,
Kenneth S. Koeneman
October 2005
October 2005
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Abstract
To evaluate the cause and significance of elevated activated partial thromboplastin
time (aPTT) in a group of patients who received a first-generation adenoviral vector
(Ad-OC-TK) delivering a toxic gene to prostate cancer cells as part of a Phase I clinical
trial at the University of Virginia.