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      Reducing Undercarboxylated Osteocalcin With Vitamin K Supplementation Does Not Promote Lean Tissue Loss or Fat Gain Over 3 Years in Older Women and Men: A Randomized Controlled Trial : EFFECT OF REDUCING UNDERCARBOXYLATED OC ON LEAN TISSUE AND FAT MASS

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      Journal of Bone and Mineral Research

      Wiley-Blackwell

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          Most cited references 32

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          Endocrine regulation of energy metabolism by the skeleton.

          The regulation of bone remodeling by an adipocyte-derived hormone implies that bone may exert a feedback control of energy homeostasis. To test this hypothesis we looked for genes expressed in osteoblasts, encoding signaling molecules and affecting energy metabolism. We show here that mice lacking the protein tyrosine phosphatase OST-PTP are hypoglycemic and are protected from obesity and glucose intolerance because of an increase in beta-cell proliferation, insulin secretion, and insulin sensitivity. In contrast, mice lacking the osteoblast-secreted molecule osteocalcin display decreased beta-cell proliferation, glucose intolerance, and insulin resistance. Removing one Osteocalcin allele from OST-PTP-deficient mice corrects their metabolic phenotype. Ex vivo, osteocalcin can stimulate CyclinD1 and Insulin expression in beta-cells and Adiponectin, an insulin-sensitizing adipokine, in adipocytes; in vivo osteocalcin can improve glucose tolerance. By revealing that the skeleton exerts an endocrine regulation of sugar homeostasis this study expands the biological importance of this organ and our understanding of energy metabolism.
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            The Loss of Skeletal Muscle Strength, Mass, and Quality in Older Adults: The Health, Aging and Body Composition Study

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              The physical activity scale for the elderly (PASE): Development and evaluation

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                Author and article information

                Journal
                Journal of Bone and Mineral Research
                J Bone Miner Res
                Wiley-Blackwell
                08840431
                February 2017
                February 2017
                : 32
                : 2
                : 243-249
                10.1002/jbmr.2989
                © 2017

                http://doi.wiley.com/10.1002/tdm_license_1

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