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      The world of subinhibitory antibiotic concentrations.

      Current Opinion in Microbiology

      Transcriptional Activation, drug effects, Transcription, Genetic, metabolism, Ribosomes, Oligonucleotide Array Sequence Analysis, Gene Expression Regulation, Bacterial, Gene Expression Profiling, Dose-Response Relationship, Drug, genetics, Bacteria, pharmacology, biosynthesis, analysis, Anti-Bacterial Agents

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          Abstract

          Although antibiotics have long been known to have multiple effects on bacterial cells at low concentrations, it is only with the advent of genome transcription analyses that these activities have been studied in detail at the level of cell metabolism. It has been shown that all antibiotics, regardless of their receptors and mode of action, exhibit the phenomenon of hormesis and provoke considerable transcription activation at low concentrations. These analyses should be of value in providing information on antibiotic side-effects, in bioactive natural product discovery and antibiotic mode-of-action studies.

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          Journal
          10.1016/j.mib.2006.08.006
          16942902

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