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      Community-associated meticillin-resistant Staphylococcus aureus.

      1 , , ,

      Lancet (London, England)

      Elsevier BV

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          Abstract

          Meticillin-resistant Staphylococcus aureus (MRSA) is endemic in hospitals worldwide, and causes substantial morbidity and mortality. Health-care-associated MRSA infections arise in individuals with predisposing risk factors, such as surgery or presence of an indwelling medical device. By contrast, many community-associated MRSA (CA-MRSA) infections arise in otherwise healthy individuals who do not have such risk factors. Additionally, CA-MRSA infections are epidemic in some countries. These features suggest that CA-MRSA strains are more virulent and transmissible than are traditional hospital-associated MRSA strains. The restricted treatment options for CA-MRSA infections compound the effect of enhanced virulence and transmission. Although progress has been made towards understanding emergence of CA-MRSA, virulence, and treatment of infections, our knowledge remains incomplete. Here we review the most up-to-date knowledge and provide a perspective for the future prophylaxis or new treatments for CA-MRSA infections.

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          Author and article information

          Journal
          Lancet
          Lancet (London, England)
          Elsevier BV
          1474-547X
          0140-6736
          May 01 2010
          : 375
          : 9725
          Affiliations
          [1 ] Laboratory of Human Bacterial Pathogenesis, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA. fdeleo@niaid.nih.gov
          Article
          S0140-6736(09)61999-1 NIHMS422176
          10.1016/S0140-6736(09)61999-1
          3511788
          20206987
          8bdb63fe-a9e4-4060-9dd6-921fc21f0c7a
          Copyright 2010 Elsevier Ltd. All rights reserved.

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