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      Cytotoxic sesquiterpene lactones from Vernonia pachyclada from the Madagascar rainforest.

      Journal of Natural Products
      American Chemical Society (ACS)

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          Abstract

          Bioassay-guided fractionation of the cytotoxic leaf extract of Vernonia pachyclada Baker led to the isolation of three new sesquiterpene lactones, designated glaucolides K-M (1-3). The structures of the new compounds were determined using 1D and 2D NMR spectroscopy, and the structure and stereochemistry of 1 were confirmed by single-crystal X-ray diffraction. Compound 3 showed moderate activity in the A2780 human ovarian cancer cell line, with an IC50 of 3.3 microM.

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          Journal
          16180816
          2539064
          10.1021/np050202e

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