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      Postprandial Changes in Cytosolic Free Calcium and Glucose Uptake in Adipocytes in Obesity and Non-Insulin-Dependent Diabetes Mellitus

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          Abstract

          We evaluated the possible relationship between [Ca<sup>2+</sup>]<sub>i</sub> and glucose uptake in the postabsorptive state and postprandially in adipocytes obtained from normal and obese subjects, as well as from patients with non-insulin-dependent diabetes mellitus (NIDDM). Adipocytes isolated from overnight-fasted obese and NIDDM patients revealed high levels of [Ca<sup>2+</sup>]<sub>i</sub> (p < 0.05 vs. control) in association with a decreased insulin-stimulated glucose uptake (p < 0.05 vs. controls). In obese and NIDDM patients treated with oral hypoglycemic agents, the overnight fasting levels of [Ca<sup>2+</sup>]<sub>i</sub> were increased postprandially (p < 0.05), concomitantly with a further decrease in insulin-stimulated 2-deoxyglucose uptake. Although the precise nature of the relationship between [Ca<sup>2+</sup>]<sub>i</sub> in specific insulin target tissues and diminished insulin action remains unknown, it is clear that high levels of [Ca<sup>2+</sup>]<sub>i</sub> may contribute to the development of insulin resistance.

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          Author and article information

          Journal
          HRE
          Horm Res Paediatr
          10.1159/issn.1663-2818
          Hormone Research in Paediatrics
          S. Karger AG
          1663-2818
          1663-2826
          1990
          1990
          02 December 2008
          : 34
          : 1
          : 39-44
          Affiliations
          Department of Medicine and Research Service of the Veterans Adminstration Medical Center, and the University of Colorado Health Sciences Center, Denver, Colo., USA
          Article
          181793 Horm Res 1990;34:39–44
          10.1159/000181793
          2074090
          © 1990 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          Page count
          Pages: 6
          Categories
          Original Paper

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