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      Postprandial Changes in Cytosolic Free Calcium and Glucose Uptake in Adipocytes in Obesity and Non-Insulin-Dependent Diabetes Mellitus

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          We evaluated the possible relationship between [Ca<sup>2+</sup>]<sub>i</sub> and glucose uptake in the postabsorptive state and postprandially in adipocytes obtained from normal and obese subjects, as well as from patients with non-insulin-dependent diabetes mellitus (NIDDM). Adipocytes isolated from overnight-fasted obese and NIDDM patients revealed high levels of [Ca<sup>2+</sup>]<sub>i</sub> (p < 0.05 vs. control) in association with a decreased insulin-stimulated glucose uptake (p < 0.05 vs. controls). In obese and NIDDM patients treated with oral hypoglycemic agents, the overnight fasting levels of [Ca<sup>2+</sup>]<sub>i</sub> were increased postprandially (p < 0.05), concomitantly with a further decrease in insulin-stimulated 2-deoxyglucose uptake. Although the precise nature of the relationship between [Ca<sup>2+</sup>]<sub>i</sub> in specific insulin target tissues and diminished insulin action remains unknown, it is clear that high levels of [Ca<sup>2+</sup>]<sub>i</sub> may contribute to the development of insulin resistance.

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          Author and article information

          Horm Res Paediatr
          Hormone Research in Paediatrics
          S. Karger AG
          02 December 2008
          : 34
          : 1
          : 39-44
          Department of Medicine and Research Service of the Veterans Adminstration Medical Center, and the University of Colorado Health Sciences Center, Denver, Colo., USA
          181793 Horm Res 1990;34:39–44
          © 1990 S. Karger AG, Basel

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          Pages: 6
          Original Paper


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