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      A comparative study of Pap smear findings among HIV positive and negative women at Government Hospital of Thoracic Medicine (GHTM), Tambaram

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      1 , , 2 , 3 , 2 , 2 , 1
      BMC Infectious Diseases
      BioMed Central
      First International Science Symposium on HIV and Infectious Diseases (HIV SCIENCE 2012)
      20-22 January 2012

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          Abstract

          Background Cancer cervix is a major health problem in India, accounting for 26.1-43.8% of all cancers in Indian women. Dysplasia on Pap smear has been reported in 15-40% of HIV positive women which is 10-11 times higher than those observed among HIV negative women. Patients with persistent inflammatory Pap smears harbor high proportion of HPV infection and cervical intraepithelial neoplasia (20.9%). The purpose of this present study was to compare Pap smear findings in HIV-infected and uninfected women at GHTM and to correlate the Pap smear abnormalities among HIV positive women with their immune status. Methodology All women (18-45 years of age), admitted at GHTM, between July-Sept. 2010, consented were selected and Pap smear was performed. Smears were reported by a pathologist blinded to the HIV status of patients. Results were analyzed by using PASW 18 version. Results Total 300 samples were collected in which 204 were HIV positive and 96 were HIV negative. HIV positive women (58.8%) had more Pap smear abnormalities such as cervical dysplasia (3.92%), inflammatory smear (51.96%), infection (2.94%) (p=0.010) when compared with HIV negative women (43.75). Among HIV positives 63.93% had CD4 count less than 250 (p=0.048), and 64.3% had coexisting opportunistic infection (p=0.04). On speculum examination, cervicitis was present in 63.3% of HIV positive women with abnormal pap smears (p=0.004). Conclusion This study showed a high percentage of inflammatory Pap smears (51.96%) among HIV positives. Hence these patients will require a follow up Pap smear and colposcopy and biopsy if inflammation is persistent to exclude cervical cancer.

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          Author and article information

          Conference
          BMC Infect Dis
          BMC Infect. Dis
          BMC Infectious Diseases
          BioMed Central
          1471-2334
          2012
          4 May 2012
          : 12
          : Suppl 1
          : P35
          Affiliations
          [1 ]Government Hospital of Thoracic Medicine (GHTM), Tambaram, Chennai, Tamil Nadu, India
          [2 ]International Training and Education Centre on Health (I-TECH India/AroGyaan), Chennai, Tamil Nadu, India
          [3 ]Arignar Anna Memorial Cancer Institute and Hospital, Kanchipuram, Tamil Nadu, India
          Article
          1471-2334-12-S1-P35
          10.1186/1471-2334-12-S1-P35
          3344754
          8bf44499-12f5-4884-9caa-5d8dab4b33fc
          Copyright ©2012 Seethalakshmi et al; licensee BioMed Central Ltd.

          This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

          First International Science Symposium on HIV and Infectious Diseases (HIV SCIENCE 2012)
          Chennai, India
          20-22 January 2012
          History
          Categories
          Poster Presentation

          Infectious disease & Microbiology
          Infectious disease & Microbiology

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