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      Failure of Diazepam to Affect Growth Hormone and Prolactin in Acromegalics

      Hormone Research in Paediatrics

      S. Karger AG

      Prolactin, <italic>L</italic>-Dopa, Effects, Diazepam, Acromegaly, Growth, Hormone

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          To demonstrate the effect of diazepam on serum growth hormone and prolactin levels in acromegaly, 7 acromegalics were studied. Every patient received 10 mg diazepam orally at zero time, and blood samples were obtained at 30-min intervals. The same patients also underwent a standard L-dopa test. They were given 500 mg L-dopa orally at zero time, and blood samples were obtained at 30-min intervals. The administration of diazepam did not induce any significant changes in either growth hormone or prolactin levels. On the other hand, the administration of L-dopa resulted in a significant decrease in growth hormone level from 74.25 ± 22 ng/ml (mean ± SEM) at zero time to a level of 52.8 ± 21 and 58.77 ± 22.7 ng/ml at the 60- and 90-min intervals, respectively (p < 0.05), and a significant decrease in prolactin level from a baseline of 56.18 ± 17 to 25.5 ± 8.4 ng/ml (p < 0.001) at the 60-min interval.It is suggested that the response of growth hormone to diazepam in acromegalics is qualitatively different from nonacromegalic controls.

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          Author and article information

          Horm Res Paediatr
          Hormone Research in Paediatrics
          S. Karger AG
          26 November 2008
          : 18
          : 4
          : 186-190
          Department of Internal Medicine, Endocrinology University of Jordan, Medical School, Amman, Jordan
          179793 Horm Res 1983;18:186–190
          © 1983 S. Karger AG, Basel

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          Pages: 5
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