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      Pathophysiology of premature skin aging induced by ultraviolet light.

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          Abstract

          Long-term exposure to ultraviolet irradiation from sunlight causes premature skin aging (photoaging), characterized in part by wrinkles, altered pigmentation, and loss of skin tone. Photoaged skin displays prominent alterations in the collagenous extracellular matrix of connective tissue. We investigated the role of matrix-degrading metalloproteinases, a family of proteolytic enzymes, as mediators of collagen damage in photoaging.

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          Author and article information

          Journal
          N Engl J Med
          The New England journal of medicine
          Massachusetts Medical Society
          0028-4793
          0028-4793
          Nov 13 1997
          : 337
          : 20
          Affiliations
          [1 ] Department of Dermatology, University of Michigan Medical School, Ann Arbor 48109-0609, USA.
          Article
          10.1056/NEJM199711133372003
          9358139
          8c01e4c5-d1a8-4d8d-a98a-4041a133a84f
          History

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