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      IDO expressing dendritic cells suppress allograft rejection of small bowel transplantation in mice by expansion of Foxp3+ regulatory T cells.

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          Abstract

          Indoleamine 2,3-dioxygenase (IDO), the enzyme that catalyzes the first and rate-limiting step of tryptophan catabolism, suppresses T-cell responses by tryptophan depletion and accumulation of kynurenine metabolites. IDO prevents allograft rejection in various transplantations.

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          Author and article information

          Journal
          Transpl. Immunol.
          Transplant immunology
          1878-5492
          0966-3274
          Oct 2015
          : 33
          : 2
          Affiliations
          [1 ] Department of General Surgery, Tianjin Medical University General Hospital, Tianjin, China.
          [2 ] Department of General Surgery, Tianjin Medical University General Hospital, Tianjin, China. Electronic address: dxc01tj@gmail.com.
          Article
          S0966-3274(15)00029-5
          10.1016/j.trim.2015.05.003
          26002283
          8c0fd088-e1a5-43b6-9dbd-2d8ad6747f41
          Copyright © 2015 Elsevier B.V. All rights reserved.
          History

          3-hydroxyanthranilic acid (3-HAA),Immune tolerance,Indoleamine 2,3-dioxygenase (IDO),Regulatory T cells (treg),Small bowel transplantation

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