The aim of this study was to investigate the prognostic value of angina pectoris threshold heart rate (ATHR) in 300 patients aged 27–65 years, suffering from typical angina pectoris and being under follow-up at our institute for at least 5 years. A multistage symptom-limited ergometric test was performed in all examinees at least twice. The patients were divided into two groups. Group 1 consisted of all those whose ATHR was 120 beats and above; group 2 with ATHR below 120 beats/min. The mean age of group 1 was 47 ± 5.8 years; the mean age of group 2 was 51 ± 5.9 years. In group 1, in 47.3% the ATHR remained unchanged within the 5-year follow-up. Of the remaining 52.7% with changes (representing 100% with changes) 19.4% died from a cardiac cause within the period of follow-up. In group 2, 56.1 % remained without ATHR changes within follow-up. In 43.9% with changes (representing 100% with changes), 48% died of a cardiac cause. Similar findings were obtained when the symptom-limited work load was taken into consideration. In group 1, which performed less than 50 W, 44.6% did not reveal any change during follow-up. In 55.4% (representing 100% with changes) 47.8% died of a cardiac cause. In group 2, patients who performed between 50 to 100 W, 52.5% were without changes. In 47.5% (representing 100% with changes) 21 % died of a cardiac cause. In group 3, patients performed more than 100 W, 54.3% were without changes, while in 45.7% (representing 100% with changes) 19.2% died of a cardiac cause. Our findings clearly indicate the significance of the ATHR as a prognostic sign.