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      Interactions of RKIP with inflammatory signaling pathways.

      1 , 1
      Critical reviews in oncogenesis

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          Abstract

          The inflammatory response plays an important role in host defense and maintenance of homeostasis, while imbalances in these responses can also lead to pathologic disease processes. Emerging data show that RKIP interacts with multiple signaling molecules that may potentiate multiple functions during inflammatory processes. Here, we review the interaction of RKIP with both the MAPK and NF-κB pathways in relation to chronic inflammatory diseases. In these settings, it can both inhibit inflammatory pathways as well contribute to pro-inflammatory signaling, often depending on the interactions with multiple proteins and perhaps lipids. The interactions of RKIP with proteins, phospholipids, fatty acids, and their enzymes thus could play a substantial role in diseases like asthma and diabetes. Targeting interactions of RKIP with these pathways could lead to novel approaches to treatment.

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          Author and article information

          Journal
          Crit Rev Oncog
          Critical reviews in oncogenesis
          0893-9675
          0893-9675
          2014
          : 19
          : 6
          Affiliations
          [1 ] University of Pittsburgh Asthma Institute at UPMC/Pulmonary Allergy and Critical Care Medicine Division, University of Pittsburgh, Pittsburgh, Pennsylvania.
          Article
          492698d1102624fd,7c3dc7df39277f91 NIHMS628415
          10.1615/CritRevOncog.2014011950
          4299596
          25597359
          8c5de9ff-8d2f-491a-b947-a9cdaaf198ea
          History

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