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      Alternatively activated (M2) macrophages promote tumour growth and invasiveness in hepatocellular carcinoma.

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          Abstract

          The roles of alternatively activated (M2) macrophages on pro-tumour phenotypes have been well documented in many cancers except hepatocellular carcinoma (HCC). Considering their close relationship with chronic tissue injuries as well as enhanced tumour invasiveness and growth, we aimed to investigate the direct effects of M2 macrophages on HCC.

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          Author and article information

          Journal
          J. Hepatol.
          Journal of hepatology
          1600-0641
          0168-8278
          Mar 2015
          : 62
          : 3
          Affiliations
          [1 ] Department of Surgery, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong, China.
          [2 ] University of Edinburgh/Medical Research Council Centre for Inflammation Research, The Queen's Medical Research Institute, Edinburgh, UK.
          [3 ] Department of Clinical Oncology, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong, China.
          [4 ] Department of Surgery, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong, China. Electronic address: kwanman@hkucc.hku.hk.
          Article
          S0168-8278(14)00795-8
          10.1016/j.jhep.2014.10.029
          25450711
          8c72a79a-547b-410e-a435-2fffc2c32e77
          Copyright © 2014 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved.
          History

          Epithelial-mesenchymal transition,Hepatocellular carcinoma,Invasiveness,M2 macrophages,Prognostic predictor

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