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      Daily Variations of Plasma Sex Hormone-Binding Globulin Binding Capacity, Testosterone and Luteinizing Hormone Concentrations in Healthy Rested Adult Males

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          In this study the daily variations of plasma sex hormone-binding globulin (SHBG) binding capacity were measured together with plasma testosterone and luteinizing hormone (LH) concentrations in 7 healthy rested adult males. Plasma SHBG-binding capacity demonstrated a significant circadian rhythm (acrophase = 2.06 p.m.; mesor = 0.35 ± 0.6 ng testosterone bound/100 ml; amplitude = 17% of the mesor). Plasma testosterone also showed a circadian rhythm (acrophase = 7.02 a.m.; mesor = 4.38 ± 0.67 ng/ml; amplitude = 18% of the mesor). The free testosterone index (or the ratio between plasma testosterone and SHBG-binding capacity) was not correlated with plasma LH levels. In our hands this last parameter did not vary according to a circadian pattern. These data are discussed in terms of a feedback mechanism controlling the pituitary-testis axis regulation.

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          Author and article information

          Horm Res Paediatr
          Hormone Research in Paediatrics
          S. Karger AG
          26 November 2008
          : 21
          : 4
          : 220-223
          aService de Radiopharmacie et Radioanalyse; bLaboratoire de Médecine expérimentale, Faculté de Médecine Alexis-Carrel, et cCentre de Médecine nucléaire, Lyon, France
          180052 Horm Res 1985;21:220–223
          © 1985 S. Karger AG, Basel

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          Pages: 4


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