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      Serum indoxyl sulfate is associated with vascular disease and mortality in chronic kidney disease patients.

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          Abstract

          As a major component of uremic syndrome, cardiovascular disease is largely responsible for the high mortality observed in chronic kidney disease (CKD). Preclinical studies have evidenced an association between serum levels of indoxyl sulfate (IS, a protein-bound uremic toxin) and vascular alterations. The aim of this study is to investigate the association between serum IS, vascular calcification, vascular stiffness, and mortality in a cohort of CKD patients.

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          Author and article information

          Journal
          Clin J Am Soc Nephrol
          Clinical journal of the American Society of Nephrology : CJASN
          American Society of Nephrology (ASN)
          1555-905X
          1555-9041
          Oct 2009
          : 4
          : 10
          Affiliations
          [1 ] INSERM ERI-12, Divisions of Clinical Pharmacology and Nephrology, Amiens University Hospital, Avenue Rene Laennec, F-80054 Amiens, France.
          Article
          CJN.03980609
          10.2215/CJN.03980609
          2758258
          19696217
          8c91059e-3622-4cdb-9cec-acb1f6e7ba5b
          History

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