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      Pubertal Growth as a Determinant of Adult Height in Boys with Constitutional Delay of Growth and Puberty

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          In boys with constitutional delay of growth and puberty, adult height may be inconsistent with parental (target) height. We aimed at studying which period of growth was important to account for adult height being above or below target height. In this retrospective study, adult height measured after 20 years in 39 patients was compared with target height and height data obtained at about 6 and 12 years of age and at diagnosis of delayed puberty (mean 14.6 years). Twenty-eight patients were untreated while 11 received testosterone enanthate (50 or 100 mg/month for 6 months). The growth data from both groups were pooled since they were not different. On average, the adult height standard deviation score (–0.6 ± 0.8, mean ± SD) was similar to target height (–0.5 ± 0.6). There were, however, marked individual differences since adult height varied between 1.7 SD (11 cm) below target height and 1.4 SD (9.5 cm) above target height. Multiple regression analysis showed that the most significant determinant of the difference between adult height and target height was height catch up during puberty (p < 0.002). We conclude that the magnitude of height catch up during puberty is a significant determinant of adult height in boys with constitutional delay of growth and puberty. Thus, optimizing pubertal growth may be a relevant therapeutic aim for adult height in boys with short stature and delayed puberty.

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          Author and article information

          Horm Res Paediatr
          Hormone Research in Paediatrics
          S. Karger AG
          May 1999
          02 November 1999
          : 51
          : 5
          : 223-229
          aDepartment of Pediatrics, Division of Ambulatory Pediatrics and Adolescent Medicine, and bDepartment of Biostatics, CHU Sart Tilman, University of Liège, Belgium
          23375 Horm Res 1999;51:223–229
          © 1999 S. Karger AG, Basel

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          Page count
          Figures: 4, Tables: 2, References: 25, Pages: 7
          Original Paper


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