Cancer of the larynx in non-smoking alcohol drinkers and in non-drinking tobacco smokers

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Abstract

The separate effect of alcohol and tobacco on laryngeal cancer was analysed in two case–control studies from Italy and Switzerland, comprising 40 non-smoking and 68 non-drinking cases, and 160 non-smoking and 161 non-drinking controls. The multivariate odds ratio was 2.46 for heavy drinkers non-smokers, and 9.38 for current smokers non-drinkers.

British Journal of Cancer (2002) 87, 516–518. doi: 10.1038/sj.bjc.6600469 www.bjcancer.com

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Smoking and drinking in relation to cancers of the oral cavity, pharynx, larynx, and esophagus in northern Italy.

S Barra, R Talamini, D Serraino … (1990)

A hospital-based case-control study of upper aerodigestive tract tumors was conducted between June 1986 and June 1989 in Northern Italy. One hundred fifty-seven male cases of oral cavity cancer, 134 of pharyngeal cancer, 162 of laryngeal cancer, and 288 of esophageal cancer, and 1272 male inpatients with acute conditions unrelated to tobacco and alcohol were interviewed. Odds ratios for current smokers of cigarettes were 11.1 for oral cavity, 12.9 for pharynx, 4.6 for larynx, and 3.8 for esophagus. For all 4 sites, the risk increased with increasing number of cigarettes and duration of smoking habits and, with the exception of esophageal cancer, decreased with increasing age at the start of and years since quitting smoking. Smokers of pipes and cigars showed a more elevated risk of cancer of the oral cavity and esophagus than did cigarette smokers. Significantly increased risks emerged also in heavy drinkers (odds ratio greater than 60 versus greater than or equal to 19 drinks/week = 3.4, 3.6, 2.1, and 6.0 for oral cavity, pharynx, larynx, and esophagus, respectively), deriving predominantly from wine consumption.

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Cancer of the larynx/hypopharynx, tobacco and alcohol: IARC international case-control study in Turin and Varese (Italy), Zaragoza and Navarra (Spain), Geneva (Switzerland) and Calvados (France).

F. Blanchet, P Boffetta, A. Moral … (1988)

A case-control study on larynx and hypopharynx cancer was carried out in 6 populations including the city of Turin and the province of Varese (Italy), the provinces of Navarra and Zaragoza (Spain), the canton of Geneva (Switzerland), and the département of Calvados (France). This report presents an analysis of the risk associated with alcohol and tobacco consumption based on 1,147 male cases and 3,057 male population controls. Special attention was given to the study of the risk at various sites of larynx and hypopharynx. The effect of tobacco is similar for all sites and the risk associated with ever smoking is on the order of 10. The risks from alcohol drinking depend on site. They are similar for epilarynx and hypopharynx (RR = 4.3, for more than 80 g/day) and lower for endolarynx (RR = 2.1, for more than 80 g/day). For all sites the risk decreases after quitting (RR = 0.3 after 10 years); exclusive use of filter cigarettes is protective (RR = 0.5 relative to smokers of plain cigarettes only) as is exclusive use of blond tobacco (RR = 0.5 relative to smokers of black tobacco only). Inhalation increases the risk of endolaryngeal cancer but not that of hypopharynx or epilarynx. The relative risks for joint exposure to alcohol and tobacco are consistent with a multiplicative model.

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Monographs on the Evaluation of Carcinogenic Risks to Humans

(2002)

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Author and article information

Journal

Journal ID (nlm-ta): Br J Cancer

Title: British Journal of Cancer

Publisher: Nature Publishing Group

ISSN (Print): 0007-0920

ISSN (Electronic): 1532-1827

Publication date (Print): 27 August 2002

Volume: 87

Issue: 5

Pages: 516-518

Affiliations

[1 ]Istituto di Ricerche Farmacologiche ‘Mario Negri’, Milan, Italy

[2 ]Field and Intervention Studies Unit, International Agency for Research on Cancer, Lyon, France

[3 ]Registre Vaudois des Tumeurs, Institut Universitaire de Médicine Sociale et Préventive, Lausanne, Switzerland

[4 ]Servizio di Epidemiologia, Centro di Riferimento Oncologico, Aviano, Italy

[5 ]Istituto di Statistica Medica e Biometria, Università degli Studi di Milano, Milan, Italy

Author notes

[* ]Author for correspondence: bosetti@ 123456marionegri.it

Article

Publisher Item ID: 6600469

DOI: 10.1038/sj.bjc.6600469

PMC ID: 2376150

PubMed ID: 12189548

SO-VID: 8c9f6351-b9b4-4bf7-846d-5b27600a2365

History

Date received : 28 March 2002

Date revision received : 17 May 2002

Date accepted : 20 May 2002

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Cancer of the larynx in non-smoking alcohol drinkers and in non-drinking tobacco smokers

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Most cited references 19

Smoking and drinking in relation to cancers of the oral cavity, pharynx, larynx, and esophagus in northern Italy.

Cancer of the larynx/hypopharynx, tobacco and alcohol: IARC international case-control study in Turin and Varese (Italy), Zaragoza and Navarra (Spain), Geneva (Switzerland) and Calvados (France).

Monographs on the Evaluation of Carcinogenic Risks to Humans

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