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      19 Strategic approaches to improve immune response against stresses in farm animals.

      abstract
      Journal of Animal Science
      Oxford University Press
      Stress, Host immune modulation, domestic animals

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          Abstract

          Modern farming industry faces a large scale and highly intensive rearing conditions, in which the goal is to maximize the production efficiency. Moreover, environmental issues including global warming and disease outbreak are another challenge that could add stressors affecting domestic animal health, both psychological and physical well-being.Major stressors in domestic animals include nutritional factors (unbalanced nutrients, toxins, and diet changes), environmental factors (quality of air and water, temperature, dust, and humidity,), biological factors (weaning, infection, castration, and injury), and physical factors (transportation, lack of spacious area, and social status). These stressors cause growth retardation coincident with modulation of immune system, especially in the gastrointestinal tract. It is rather obvious that deficiency in nutrients causes immune function impairment, which can be reversed by nutrient repletion. Nutritional deficiencies in animals with infectious diseases are the main contributor to a high morbidity and mortality.In my talk, I will focus on some of stressors in relation to host immune responses in major domestic animals using in vitro and in vivo model systems. Furthermore, toxins and/or microbial metabolites in the presence and absence of antigenic stimulation causing destruction of tight junctions and intestinal epithelial cells will be discussed. The audience will gain insight on the action mechanism of (1) stress and modulation of host immune responses, (2) vaccine and adjuvants, and (3) nutritional balance, microbiota and immune modulation in domestic animals.

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          Author and article information

          Journal
          J Anim Sci
          J. Anim. Sci
          jansci
          Journal of Animal Science
          Oxford University Press (US )
          0021-8812
          1525-3163
          December 2018
          07 December 2018
          : 96
          : Suppl 3
          : 2-3
          Affiliations
          Colleage of Agriculture and Life Sciences, Seoul National University,Seoul, Republic of Korea
          Article
          PMC6285985 PMC6285985 6285985 sky404.004
          10.1093/jas/sky404.004
          6285985
          8cadb812-a02e-4ba0-b863-16088d13e817
          © The Author(s) 2018. Published by Oxford University Press on behalf of the American Society of Animal Science. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

          This article is published and distributed under the terms of the Oxford University Press, Standard Journals Publication Model ( https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model)

          History
          Page count
          Pages: 2
          Categories
          Abstracts
          3rd International Animal Sciences and Biotechnology Forum

          domestic animals,Host immune modulation,Stress
          domestic animals, Host immune modulation, Stress

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