Pentoxifylline suppresses renal tumour necrosis factor-alpha and ameliorates experimental crescentic glomerulonephritis in rats.

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Abstract

Crescentic glomerulonephritis is a rapidly progressive form of glomerulonephritis, but treatment remains non-specific. The methylxanthine derivative pentoxifylline (PTX) is a clinically available phosphodiesterase inhibitor with anti-inflammatory and immunoregulatory activities. This study examined whether PTX has beneficial effects in a rat model of anti-glomerular basement membrane (GBM) crescentic glomerulonephritis.

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Journal

Journal ID (iso-abbrev): Nephrol. Dial. Transplant.

Title: Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association

Publisher: Oxford University Press (OUP)

ISSN: 0931-0509

ISSN (Print): 0931-0509

Publication date (Electronic): May 2004

Volume: 19

Issue: 5

Affiliations

[1 ] Department of Medicine, National Taiwan University Hospital and College of Medicine, National Taiwan University, Taipei, Taiwan.

Article

Publisher Item ID: gfh127

DOI: 10.1093/ndt/gfh127

PubMed ID: 14993492

SO-VID: 8cae12c5-1c40-4b57-ab6f-9c88b0109a7f

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