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An Atlas of Combinatorial Transcriptional Regulation in Mouse and Man
Timothy Ravasi ,
Harukazu Suzuki ,
Carlo Vittorio Cannistraci ,
Shintaro Katayama ,
Vladimir B. Bajic ,
Kai Tan ,
Altuna Akalin ,
Sebastian Schmeier ,
Mutsumi Kanamori-Katayama ,
Nicolas Bertin ,
Piero Carninci ,
Carsten O. Daub ,
Alistair R.R. Forrest ,
Julian Gough ,
Sean Grimmond ,
Jung-Hoon Han ,
Takehiro Hashimoto ,
Winston Hide ,
Oliver Hofmann ,
Atanas Kamburov ,
Mandeep Kaur ,
Hideya Kawaji ,
Atsutaka Kubosaki ,
Timo Lassmann ,
Erik van Nimwegen ,
Cameron Ross MacPherson ,
Chihiro Ogawa ,
Aleksandar Radovanovic ,
Ariel Schwartz ,
Rohan D. Teasdale ,
Jesper Tegnér ,
Boris Lenhard ,
Sarah A. Teichmann ,
Takahiro Arakawa ,
Noriko Ninomiya ,
Kayoko Murakami ,
Michihira Tagami ,
Shiro Fukuda ,
Kengo Imamura ,
Chikatoshi Kai ,
Ryoko Ishihara ,
Yayoi Kitazume ,
Jun Kawai ,
David A. Hume ,
Trey Ideker ,
Yoshihide Hayashizaki
March 2010
March 2010
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Abstract
Combinatorial interactions among transcription factors are critical to directing tissue-specific
gene expression. To build a global atlas of these combinations, we have screened for
physical interactions among the majority of human and mouse DNA-binding transcription
factors (TFs). The complete networks contain 762 human and 877 mouse interactions.
Analysis of the networks reveals that highly connected TFs are broadly expressed across
tissues, and that roughly half of the measured interactions are conserved between
mouse and human. The data highlight the importance of TF combinations for determining
cell fate, and they lead to the identification of a SMAD3/FLI1 complex expressed during
development of immunity. The availability of large TF combinatorial networks in both
human and mouse will provide many opportunities to study gene regulation, tissue differentiation,
and mammalian evolution.
(c) 2010 Elsevier Inc. All rights reserved.