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      Pre-Pubertal Gynaecomastia as the Presenting Feature of Late-Onset 21-Hydroxylase Deficiency

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          Abstract

          We describe an 8-year-old boy with pre-pubertal gynaecomastia as the presenting feature of late-onset 21-hydroxylase deficiency, an association not previously reported. Although absolute oestrogen levels were not higher than previously described in 21 -hydroxylase deficiency, the gynaecomastia may have arisen through a relative disproportion of the C<sub>18</sub> to C<sub>19</sub> steroids.

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          Author and article information

          Journal
          HRE
          Horm Res Paediatr
          10.1159/issn.1663-2818
          Hormone Research in Paediatrics
          S. Karger AG
          978-3-8055-4415-3
          978-3-318-05738-6
          1663-2818
          1663-2826
          1985
          1985
          26 November 2008
          : 22
          : 1-2
          : 94-99
          Affiliations
          aDepartment of Child Health, University of Aberdeen; bDepartment of Child Health, University of Dundee; cDepartment of Chemical Pathology, The Royal Infirmary, Glasgow, and dDepartment of Clinical Endocrinology, Birmingham Hospitals, Birmingham, UK
          Article
          180079 Horm Res 1985;22:94–99
          10.1159/000180079
          2411646
          © 1985 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          Page count
          Pages: 6
          Categories
          Pediatric Endocrinology

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