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      Serum Hepatocyte Growth Factor Levels in Patients with Renal Diseases

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          The serum levels of hepatocyte growth factor (HGF) were determined in patients with various renal diseases. In patients with acute-phase acute renal failure (ARF) and chronic tubulointerstitial nephritis (chronic TIN), the serum HGF levels were 0.55 ± 0.24 and 0.44 ± 0.37 ng/ml (mean ± SD), respectively, and were significantly higher than that in the control group (0.12 ± 0.12 ng/ml). The serum HGF level tended to be high also in patients with active-phase steroid-sensitive nephrotic syndrome (SSNS). The serum levels of HGF were not elevated in patients with IgA nephropathy (IgAN), Henoch-Schönlein purpura nephritis (HSPN), membranoproliferative glomerulonephritis (MPGN), poststreptococcal acute glomerulonephritis (PSAGN), unilateral renal atrophy, unilateral nephrectomy, or proximal tubular dysfunction. These observations suggest that glomerular disorders cause no apparent elevation of the serum HGF level, and that elevation of the serum HGF level may be associated with tubulointerstitial damage in renal diseases.

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          Molecular cloning and expression of human hepatocyte growth factor.

          Hepatocyte growth factor (HGF) is the most potent mitogen for mature parenchymal hepatocytes in primary culture, and seems to be a hepatotrophic factor that acts as a trigger for liver regeneration after partial hepatectomy and liver injury. The partial purification and characterization of HGF have been reported. We have demonstrated that pure HGF from rat platelets is a new growth factor effective at concentrations as low as 1 ng ml-1. The effects of HGF and epidermal growth factor (EGF) are additive. The activity of HGF is not species-specific, although it does not stimulate growth in Swiss 3T3 fibroblasts. HGF has a relative molecular mass (Mr) of 82,000 and is a heterodimer composed of a large alpha-subunit of Mr 69,000 and a small beta-subunit of Mr 34,000. Here we report the amino-acid sequence of human HGF determined by complementary DNA cloning and the expression of biologically active human HGF from COS-1 cells transfected with cloned cDNA. The nucleotide sequence of the human HGF cDNA reveals that both alpha- and beta-chains are contained in a single open reading frame coding for a pre-pro precursor protein of 728 amino acids.
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            Pro and contra in minimally invasive oncological surgery


              Author and article information

              Am J Nephrol
              American Journal of Nephrology
              S. Karger AG
              August 1999
              13 August 1999
              : 19
              : 4
              : 509-512
              Departments of aPediatrics, and bClinical Laboratory and Medicine, Kyoto Prefectural University of Medicine, Kyoto, Japan
              13508 Am J Nephrol 1999;19:509–512
              © 1999 S. Karger AG, Basel

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              Page count
              Figures: 1, Tables: 1, References: 16, Pages: 4
              Self URI (application/pdf):
              Clinical Study

              Cardiovascular Medicine, Nephrology

              Hepatocyte growth factor, Renal diseases, Childhood


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