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      Autoantibodies and decreased expression of the transcription factor ELF-3 together with increased chemokine pathways support an autoimmune phenotype and altered differentiation in lichen planus located in oral mucosa.

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          Abstract

          The pathogenesis of oral lichen planus (OLP), a chronic inflammatory disease, is not fully understood. It is known that OLP has autoimmune features, and it is suggested to be an autoimmune disease. ELF-3 is involved in differentiation of keratinocytes and deregulated in different tumours and inflammatory diseases. CXCR-3 and its ligands CXCL-10 and CXCL-11 are increased in autoimmune diseases and linked to Th-1 immune response.

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          Author and article information

          Journal
          J Eur Acad Dermatol Venereol
          Journal of the European Academy of Dermatology and Venereology : JEADV
          1468-3083
          0926-9959
          Nov 2013
          : 27
          : 11
          Affiliations
          [1 ] Department of Odontology, Umeå UniversityDepartment of Medical Biosciences, Umeå University, Umeå, SwedenTayside Tissue Bank/Medical Research Institute, University of Dundee, Ninewells Hospital and Medical School, Dundee, UKDepartment of Clinical Medicine and Public Health/Dermatology and Venerology, Umeå University, Umeå, Sweden.
          Article
          10.1111/jdv.12027
          23134363
          © 2012 The Authors. Journal of the European Academy of Dermatology and Venereology © 2012 European Academy of Dermatology and Venereology.

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