Autoantibodies and decreased expression of the transcription factor ELF-3 together with increased chemokine pathways support an autoimmune phenotype and altered differentiation in lichen planus located in oral mucosa.

There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

Abstract

The pathogenesis of oral lichen planus (OLP), a chronic inflammatory disease, is not fully understood. It is known that OLP has autoimmune features, and it is suggested to be an autoimmune disease. ELF-3 is involved in differentiation of keratinocytes and deregulated in different tumours and inflammatory diseases. CXCR-3 and its ligands CXCL-10 and CXCL-11 are increased in autoimmune diseases and linked to Th-1 immune response.

Related collections

Author and article information

Journal

Journal ID (iso-abbrev): J Eur Acad Dermatol Venereol

Title: Journal of the European Academy of Dermatology and Venereology : JEADV

ISSN (Electronic): 1468-3083

ISSN (Print): 0926-9959

Publication date (Electronic): Nov 2013

Volume: 27

Issue: 11

Affiliations

[1 ] Department of Odontology, Umeå UniversityDepartment of Medical Biosciences, Umeå University, Umeå, SwedenTayside Tissue Bank/Medical Research Institute, University of Dundee, Ninewells Hospital and Medical School, Dundee, UKDepartment of Clinical Medicine and Public Health/Dermatology and Venerology, Umeå University, Umeå, Sweden.

Article

DOI: 10.1111/jdv.12027

PubMed ID: 23134363

SO-VID: 8cf2f56f-c719-4bda-835a-bfd7da2ad8c6

History

Data availability:

Comments

Comment on this article

scite_

Cited by 7

See all cited by