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      Interactions between the Pituitary, Thyroid and Adrenal Cortex during Acute Exposure to Cold or to Electric Shocks in the Rat

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          Abstract

          In intact rats acclimated to 25 ± 1°C, acute exposure to cold resulted in simultaneous stimulation of TSH and ACTH secretion. The plasma TSH response to cold was identical at temperatures varying from + 14 to -10°C, whereas the adrenocortical response increased proportionally to the severity of cold. Acute stimulation of ACTH secretion by exposure to a stressful situation (electrical shocks) did not alter the TSH response to cold. Conversely, acute blockade of the pituitary-adrenocortical response by dexamethasone treatment did not enhance the TSH response to cold. Chronic stimulation of ACTH secretion resulting from adrenalectomy did not interfere with the TSH response during subsequent exposure to cold. However, a reduced adrenocortical response to cold was observed during chronic hypersecretion of TSH resulting from previous thyroidectomy. These findings do not support the hypothesis of an inverse relationship between TSH and ACTH secretions during acute cold exposure, but rather suggest that these secretions are independent.

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          Author and article information

          Journal
          HRE
          Horm Res Paediatr
          10.1159/issn.1663-2818
          Hormone Research in Paediatrics
          S. Karger AG
          1663-2818
          1663-2826
          1975
          1975
          21 November 2008
          : 6
          : 4
          : 199-212
          Affiliations
          Laboratoire d’Endocrinologie-Biocontrôles, Département de Physiologie, Faculté de Médecine, Université Laval, Quebec, Que.
          Article
          178694 Horm Res 1975;6:199–212
          10.1159/000178694
          178586
          © 1975 S. Karger AG, Basel

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          Page count
          Pages: 14
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