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      Is the main lacrimal gland indispensable? Contributions of the corneal and conjunctival epithelia.

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          Abstract

          The ocular surface system is responsible for ensuring that the precorneal tear film is sufficient in both quality and quantity to preserve optimal vision. Tear secretion is a complex, multifactorial process, and dysfunction of any component of the ocular surface system can result in tear film instability and hyperosmolarity with resultant dry eye disease. The tear film is primarily composed of lipids, aqueous, and mucins, with aqueous accounting for most of its thickness. The aqueous is produced by the main lacrimal gland, accessory lacrimal glands, and corneal and conjunctival epithelia. Although the main lacrimal gland has long been considered an indispensable source of the aqueous component of tears, there is evidence that adequate tear secretion can exist in the absence of the main lacrimal gland. We review and discuss the basics of tear secretion, the tear secretory capacity of the ocular surface, and emerging treatments for dry eye disease.

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          Author and article information

          Journal
          Surv Ophthalmol
          Survey of ophthalmology
          Elsevier BV
          1879-3304
          0039-6257
          March 13 2016
          : 61
          : 5
          Affiliations
          [1 ] Department of Ophthalmology and Vision Science, The University of Arizona College of Medicine, Tucson, Arizona, USA.
          [2 ] PSG Institute of Medical Sciences and Research, Coimbatore, Tamil Nadu, India.
          [3 ] Department of Ophthalmology and Vision Science, The University of Arizona College of Medicine, Tucson, Arizona, USA. Electronic address: mwang@eyes.arizona.edu.
          Article
          S0039-6257(15)30066-7
          10.1016/j.survophthal.2016.02.006
          26968256

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