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      Progressive Decline in Renal Function Induces a Gradual Decrease in Total Hemoglobin and Exercise Capacity

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          We examined 58 patients (38 men, 20 women; mean age: 45 ± 12 years; body mass index: 24 ± 4 kg/m<sup>2</sup>) with a glomerular filtration rate (GFR) ranging from 3 to 32 ml/min, in order to determine the effects of a progressive decline in renal function on total hemoglobin (THb) and exercise capacity. The THb ranged from 185 to 759 g and the hemoglobin concentration ranged from 66 to 151 g/l. Maximal exercise capacity ranged from 50 to 260 W (40-143% of the expected norm). Nearly all the patients interrupted their exercise tests due to general fatigue, leg tiredness or a combination of these factors. There was a sigificant partial correlation between THb and GFR after sex and age had been accounted for (r = 0.39; p < 0.005). Maximal exercise capacity and THb showed a significant partial correlation after sex, age and GFR had been accounted for (r = 0.27; p < 0.05). Maximal exercise capacity showed a significant partial correlation with GFR after sex, age and THb had been accounted for (r = 0.30; p < 0.05). In conclusion, there is a gradual decline in THb and maximal exercise capacity as uremia progresses. Anemia appears to be a contributory cause responsible for the decrease in maximal exercise capacity along with other factors pertinent to uremia per se.

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          Author and article information

          S. Karger AG
          17 December 2008
          : 67
          : 3
          : 322-326
          aDivision of Nephrology, Department of Internal Medicine, bDepartment of Clinical Physiology, Huddinge Hospital and cDepartment of Cardiology, Karolinska Hospital, Stockholm, Sweden
          187987 Nephron 1994;67:322–326
          © 1994 S. Karger AG, Basel

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          Pages: 5
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