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      Receptor Subtypes Involved in Relaxation and Contraction by Arginine Vasopressin in Canine Isolated Short Posterior Ciliary Arteries


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          Arginine vasopressin (AVP) produced relaxations at low concentrations (10<sup>-11</sup>and 10<sup>-10</sup> M)and contractions at higher concentrations in canine ciliary arterial strips with endothelium, partially contracted with prostglandin F<sub>2α</sub>. The AVP-induced relaxation was abolished or reversed to a contraction by removal of the endothelium or treatment with N<sup>G</sup>-nitro- L-arginine. The effect of this antagonist was reversed by L-arginine. The relaxant response was inhibited dose-dependently by SR49059 (10<sup>–10</sup>–10<sup>–9</sup>M) , [Pmp<sup>1</sup>Tyr(Me)<sup>2</sup>]<sup>-</sup>Arg<sup>8</sup>-vasopressin (PMP-AVP) (10<sup>–10</sup>–10<sup>–9</sup> M) , V<sub>1</sub> receptor antagonists, and OPC31260 (3 × 10<sup>-8</sup> M) , a reported V<sub>2</sub> receptor antagonist, but not by OPC21268 (10<sup>–7</sup>–10<sup>–6</sup> M) , a reported V<sub>1</sub> antagonist. In the endothelium-denuded strips, the AVP-induced contraction was attenuated by SR49059, PMP-AVP and OPC31260, but not by OPC21268. It is concluded that AVP in low concentrations elicits intense relaxation of canine ciliary arteries, possibly due to nitric oxide synthesized in association with activation of the endothelial V<sub>1</sub> receptor subtype. AVP-induced contractions appear to be mediated also by the V<sub>1</sub> receptor in smooth muscle. Antagonistic selectivities of the OPC compounds to vasopressin receptor subtypes could not be seen in this particular material.

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          Author and article information

          J Vasc Res
          Journal of Vascular Research
          S. Karger AG
          24 September 2008
          : 34
          : 6
          : 464-472
          Department of Pharmacology, Shiga University of Medical Science, Seta, Japan
          159257 J Vasc Res 1997;34:464–472
          © 1997 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          : 22 October 1996
          : 27 June 1997
          Page count
          Pages: 9
          Research Paper

          General medicine,Neurology,Cardiovascular Medicine,Internal medicine,Nephrology
          Arginine vasopressin,Endothelium,Ciliary artery,Vasopressin receptor subtype,Nitric oxide


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