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      Stress and Health: Psychological, Behavioral, and Biological Determinants

      1 , 1 , 1
      Annual Review of Clinical Psychology
      Annual Reviews

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          Abstract

          Stressors have a major influence upon mood, our sense of well-being, behavior, and health. Acute stress responses in young, healthy individuals may be adaptive and typically do not impose a health burden. However, if the threat is unremitting, particularly in older or unhealthy individuals, the long-term effects of stressors can damage health. The relationship between psychosocial stressors and disease is affected by the nature, number, and persistence of the stressors as well as by the individual's biological vulnerability (i.e., genetics, constitutional factors), psychosocial resources, and learned patterns of coping. Psychosocial interventions have proven useful for treating stress-related disorders and may influence the course of chronic diseases.

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          Most cited references11

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          Causal explanations as a risk factor for depression: theory and evidence.

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            Chronic psychological stress and the regulation of pro-inflammatory cytokines: a glucocorticoid-resistance model.

            This study examined whether chronic stress impairs the immune system's capacity to respond to hormonal signals that terminate inflammation. Fifty healthy adults were studied; half were parents of cancer patients, and half were parents of healthy children. Parents of cancer patients reported more psychological distress than parents of healthy children. They also had flatter diurnal slopes of cortisol secretion, primarily because of reduced output during the morning hours. There was also evidence that chronic stress impaired the immune system's response to anti-inflammatory signals: The capacity of a synthetic glucocorticoid hormone to suppress in vitro production of the pro-inflammatory cytokine interleukin-6 was diminished among parents of cancer patients. Findings suggest a novel pathway by which chronic stress might alter the course of inflammatory disease.
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              Types of stressors that increase susceptibility to the common cold in healthy adults.

              Two-hundred seventy-six volunteers completed a life stressor interview and psychological questionnaires and provided blood and urine samples. They were then inoculated with common cold viruses and monitored for the onset of disease. Although severe acute stressful life events (less than 1 month long) were not associated with developing colds, severe chronic stressors (1 month or longer) were associated with a substantial increase in risk of disease. This relation was attributable primarily to under- or unemployment and to enduring interpersonal difficulties with family or friends. The association between chronic stressors and susceptibility to colds could not be fully explained by differences among stressed and nonstressed persons in social network characteristics, personality, health practices, or prechallenge endocrine or immune measures.
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                Author and article information

                Journal
                Annual Review of Clinical Psychology
                Annu. Rev. Clin. Psychol.
                Annual Reviews
                1548-5943
                1548-5951
                April 2005
                April 2005
                : 1
                : 1
                : 607-628
                Affiliations
                [1 ]Department of Psychology, University of Miami, Coral Gables, Florida 33124-0751; email: , ,
                Article
                10.1146/annurev.clinpsy.1.102803.144141
                2568977
                17716101
                8d2ef456-25e4-4bd8-9e8b-5a712554b8de
                © 2005
                History

                Sociology,Psychology,Anthropology,Social & Behavioral Sciences,General social science,General behavioral science

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