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      Stress and Auto-Immune Endocrine Diseases

      ,

      Hormone Research in Paediatrics

      S. Karger AG

      Stress, Auto-immunity, Graves’ disease, Insulin-dependent diabetes

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          Abstract

          Auto-immunity may occur in all endocrine tissues, with a particular prevalence in thyroid and pancreatic islets. The most demonstrative clinical expressions of this auto-immunity are Graves’ disease and insulin dependent diabetes. In the former, extensive data are available upon the immunological disorders seen in peripheral blood as well as in the thyroid itself. The predisposal profile of such diseases is quite well delineated (genetic markers in HLA system, organ-specific T suppressive deficiency). On the other hand, the mechanisms implicated in the onset of auto-immunity are still questioned, the classical viral infection being scarcely demonstrated. Clinical observation registers frequent stressful life events just before the onset of these diseases, but there are few convincing data in the literature. The recent findings on the close relations between the immune system and the central nervous system lead to conceive an actual psychoneuro-endocrine-immune axis. This axis might explain the eventual priming effect of stress in patients predisposed for an organ-specific auto-immunity.

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          Author and article information

          Journal
          HRE
          Horm Res Paediatr
          10.1159/issn.1663-2818
          Hormone Research in Paediatrics
          S. Karger AG
          978-3-8055-5037-6
          978-3-318-01982-7
          1663-2818
          1663-2826
          1989
          1989
          28 November 2008
          : 31
          : 1-2
          : 90-93
          Affiliations
          Clinique Médicale et Endocrinologique, CHU de Nancy, Hôpital de Brabois, Nancy-Vandœuvre, France
          Article
          181094 Horm Res 1989;31:90–93
          10.1159/000181094
          2722141
          © 1989 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          Page count
          Pages: 4
          Categories
          Neuroendocrinology 1988

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