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Tumour-infiltrating lymphocytes and prognosis in different subtypes of breast cancer: a pooled analysis of 3771 patients treated with neoadjuvant therapy
Carsten Denkert ,
Gunter von Minckwitz ,
Silvia Darb-Esfahani ,
Bianca Lederer ,
Barbara I Heppner ,
Karsten E Weber ,
Jan Budczies ,
Jens Huober ,
Frederick Klauschen ,
Jenny Furlanetto ,
Wolfgang D Schmitt ,
Jens-Uwe Blohmer ,
Thomas Karn ,
Berit M Pfitzner ,
Sherko Kümmel ,
Knut Engels ,
Andreas Schneeweiss ,
Arndt Hartmann ,
Aurelia Noske ,
Peter A Fasching ,
Christian Jackisch ,
Marion van Mackelenbergh ,
Peter Sinn ,
Christian Schem ,
Claus Hanusch ,
Michael Untch ,
Sibylle Loibl
January 2018
January 2018
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Abstract
Tumour-infiltrating lymphocytes (TILs) are predictive for response to neoadjuvant
chemotherapy in triple-negative breast cancer (TNBC) and HER2-positive breast cancer,
but their role in luminal breast cancer and the effect of TILs on prognosis in all
subtypes is less clear. Here, we assessed the relevance of TILs for chemotherapy response
and prognosis in patients with TNBC, HER2-positive breast cancer, and luminal-HER2-negative
breast cancer.