11
views
0
recommends
+1 Recommend
1 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: found
      Is Open Access

      Epidemiological characteristics of 2019-ncoV infections in Shaanxi, China by February 8, 2020

      letter

      Read this article at

      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          In December, 2019, a new coronavirus named 2019-nCoV causing severe acute respiratory disease has emerged in the region of Wuhan, China [1, 2]. The National Health Commission of People's Republic of China named pneumonia infected with 2019-nCoV as Novel Coronavirus Pneumonia (NCP).Evidence have pointing to the person-to-person transmission [3–5]. As of February 8, 2020, China has reported 34 673 confirmed and more than 27 657 suspected cases of NCP across 34 Chinese provinces or municipalities, with 106 fatalities. Most of the studies focused on the epidemic situation in Wuhan, but few on provinces outside Wuhan. Shaanxi is located in the northwest of Hubei Province and adjacent to it, with a population of 38.64 million. Since the first case of NCP was confirmed in Shannxi by on January 23, 2020, 195 cases have been confirmed, but there is no relevant epidemiological study. In order to better understand the epidemic law of new coronavirus in Shaanxi Province, and provide the basis for the future development of control measures.This article aims to report the epidemiological outcomes of 195 confirmed case infected with 2019-nCoV in Shaanxi, and to compare the clinical features between patients with or without a history of exposure in Wuhan.

          Abstract

          The patients confirmed with NCP in Shaanxi Province are mainly have the history of Wuhan contact, There are characteristics of family aggregation and concealment.

          Related collections

          Most cited references7

          • Record: found
          • Abstract: found
          • Article: not found

          Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China

          Summary Background A recent cluster of pneumonia cases in Wuhan, China, was caused by a novel betacoronavirus, the 2019 novel coronavirus (2019-nCoV). We report the epidemiological, clinical, laboratory, and radiological characteristics and treatment and clinical outcomes of these patients. Methods All patients with suspected 2019-nCoV were admitted to a designated hospital in Wuhan. We prospectively collected and analysed data on patients with laboratory-confirmed 2019-nCoV infection by real-time RT-PCR and next-generation sequencing. Data were obtained with standardised data collection forms shared by WHO and the International Severe Acute Respiratory and Emerging Infection Consortium from electronic medical records. Researchers also directly communicated with patients or their families to ascertain epidemiological and symptom data. Outcomes were also compared between patients who had been admitted to the intensive care unit (ICU) and those who had not. Findings By Jan 2, 2020, 41 admitted hospital patients had been identified as having laboratory-confirmed 2019-nCoV infection. Most of the infected patients were men (30 [73%] of 41); less than half had underlying diseases (13 [32%]), including diabetes (eight [20%]), hypertension (six [15%]), and cardiovascular disease (six [15%]). Median age was 49·0 years (IQR 41·0–58·0). 27 (66%) of 41 patients had been exposed to Huanan seafood market. One family cluster was found. Common symptoms at onset of illness were fever (40 [98%] of 41 patients), cough (31 [76%]), and myalgia or fatigue (18 [44%]); less common symptoms were sputum production (11 [28%] of 39), headache (three [8%] of 38), haemoptysis (two [5%] of 39), and diarrhoea (one [3%] of 38). Dyspnoea developed in 22 (55%) of 40 patients (median time from illness onset to dyspnoea 8·0 days [IQR 5·0–13·0]). 26 (63%) of 41 patients had lymphopenia. All 41 patients had pneumonia with abnormal findings on chest CT. Complications included acute respiratory distress syndrome (12 [29%]), RNAaemia (six [15%]), acute cardiac injury (five [12%]) and secondary infection (four [10%]). 13 (32%) patients were admitted to an ICU and six (15%) died. Compared with non-ICU patients, ICU patients had higher plasma levels of IL2, IL7, IL10, GSCF, IP10, MCP1, MIP1A, and TNFα. Interpretation The 2019-nCoV infection caused clusters of severe respiratory illness similar to severe acute respiratory syndrome coronavirus and was associated with ICU admission and high mortality. Major gaps in our knowledge of the origin, epidemiology, duration of human transmission, and clinical spectrum of disease need fulfilment by future studies. Funding Ministry of Science and Technology, Chinese Academy of Medical Sciences, National Natural Science Foundation of China, and Beijing Municipal Science and Technology Commission.
            Bookmark
            • Record: found
            • Abstract: found
            • Article: not found

            A Novel Coronavirus from Patients with Pneumonia in China, 2019

            Summary In December 2019, a cluster of patients with pneumonia of unknown cause was linked to a seafood wholesale market in Wuhan, China. A previously unknown betacoronavirus was discovered through the use of unbiased sequencing in samples from patients with pneumonia. Human airway epithelial cells were used to isolate a novel coronavirus, named 2019-nCoV, which formed a clade within the subgenus sarbecovirus, Orthocoronavirinae subfamily. Different from both MERS-CoV and SARS-CoV, 2019-nCoV is the seventh member of the family of coronaviruses that infect humans. Enhanced surveillance and further investigation are ongoing. (Funded by the National Key Research and Development Program of China and the National Major Project for Control and Prevention of Infectious Disease in China.)
              Bookmark
              • Record: found
              • Abstract: found
              • Article: found

              Clinical Characteristics of 138 Hospitalized Patients With 2019 Novel Coronavirus–Infected Pneumonia in Wuhan, China

              In December 2019, novel coronavirus (2019-nCoV)-infected pneumonia (NCIP) occurred in Wuhan, China. The number of cases has increased rapidly but information on the clinical characteristics of affected patients is limited.
                Bookmark

                Author and article information

                Journal
                Eur Respir J
                Eur. Respir. J
                ERJ
                erj
                The European Respiratory Journal
                European Respiratory Society
                0903-1936
                1399-3003
                05 March 2020
                : 2000310
                Affiliations
                [1 ]Department of Pulmonary and Critical Care Medicine, The Xi'an Medical University Affiliated Hospital, Xi'an, Shaanxi, PR China
                [2 ]Yao Y and Tian Y have contributed equally to this work
                Author notes
                Dr Wang SY, MD, Department of Pulmonary and Critical Care Medicine, The First Affiliated Hospital of Xi'an Medical University, Xi'an, Shaanxi, PR China. E-mail: wangshengyu@ 123456yeah.net
                Author information
                https://orcid.org/0000-0002-5437-1558
                Article
                ERJ-00310-2020
                10.1183/13993003.00310-2020
                7098480
                32139462
                8d61ff12-860b-4757-938a-25bb952cf659
                Copyright ©ERS 2020

                This article is open access and distributed under the terms of the Creative Commons Attribution Non-Commercial Licence 4.0.

                History
                : 10 February 2020
                : 22 February 2020
                Categories
                Research Letter

                Respiratory medicine
                Respiratory medicine

                Comments

                Comment on this article