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      Differential Distribution of Insulin-Like Growth Factor-1 and Insulin-Like Growth Factor Binding Proteins in Experimental Diabetic Rat Kidney

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          Insulin-like growth factor-1 (IGF-1) is a peptide growth factor, and its activity is modulated by interaction with the family of IGF binding proteins (IGFBP-1 to 6). IGF-1 is detected in rat kidney and has metabolic and growth effects. To explore the possible involvement of IGFBPs in glomerular hypertrophy in streptozotocin (STZ)-induced diabetic rat, the immunolocalization of IGF-1 and IGFBPs were investigated. IGF-1 was gradually increased in the glomeruli of diabetic rats and correlated with glomerular hypertrophy. IGFBP-1 was transiently increased at 1 week after the STZ injection and declined to control level during the following period. In contrast, IGFBP-4 was increased in the diabetic glomeruli throughout the observation period. With insulin treatment, the levels of IGF-1, IGFBP-1 and 4 were normalized and glomerular hypertrophy was prevented. Initial glomerular hypertrophy of diabetic nephropathy is a related IGF-1 action, which may be modulated by IGFBP-1 and 4.

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          Author and article information

          S. Karger AG
          March 1999
          26 February 1999
          : 81
          : 3
          : 317-323
          aDepartment of Medicine III, Okayama University Medical School, Okayama, and bDepartment of Applied Animal Sciences, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Japan
          45299 Nephron 1999;81:317–323
          © 1999 S. Karger AG, Basel

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          Figures: 7, Tables: 2, References: 47, Pages: 7
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