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      Sex difference and estrous cycle variations in amphetamine-elicited rotational behavior

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      European Journal of Pharmacology
      Elsevier BV

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          Abstract

          The experiments reported here were designed to determine if there are sex- and/or estrus cycle-dependent differences in amphetamine (AMPH)-elicited rotational behavior in unlesioned rats. Whole brain or striatal levels of AMPH produced by systemic administration of the drug were also measured. At all doses tested (1.0-10.0 mg/kg) systemic administration of AMPH resulted in significantly higher brain levels of AMPH in females than in males. A systemic dose was then calculated which produced equivalent brain levels of AMPH in males and females. Even with equivalent brain levels of AMPH, males produced significantly fewer net rotations than females in estrus, diestrus 2, or proestrus. In female rats the brain levels of AMPH produced by systemic administration did not vary with the estrous cycle. However, the amount of AMPH-elicited rotational behavior did. On the day of estrus, female produced significantly more net rotations than they did 24 h later, on the day of diestrus 1. It is suggested that sex and estrous cycle dependent differences in rotational behavior may be due to the direct or indirect modulation of mesostriatal dopamine activity by gonadal steroid hormone.

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          Author and article information

          Journal
          European Journal of Pharmacology
          European Journal of Pharmacology
          Elsevier BV
          00142999
          May 1982
          May 1982
          : 80
          : 1
          : 65-72
          Article
          10.1016/0014-2999(82)90178-9
          7201404
          8d7d6225-73ca-45df-a160-0973f5884f8c
          © 1982

          https://www.elsevier.com/tdm/userlicense/1.0/

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