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      Role of nrf2 in oxidative stress and toxicity.

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      Annual review of pharmacology and toxicology
      Annual Reviews

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          Abstract

          Organismal life encounters reactive oxidants from internal metabolism and environmental toxicant exposure. Reactive oxygen and nitrogen species cause oxidative stress and are traditionally viewed as being harmful. On the other hand, controlled production of oxidants in normal cells serves useful purposes to regulate signaling pathways. Reactive oxidants are counterbalanced by complex antioxidant defense systems regulated by a web of pathways to ensure that the response to oxidants is adequate for the body's needs. A recurrent theme in oxidant signaling and antioxidant defense is reactive cysteine thiol-based redox signaling. The nuclear factor erythroid 2-related factor 2 (Nrf2) is an emerging regulator of cellular resistance to oxidants. Nrf2 controls the basal and induced expression of an array of antioxidant response element-dependent genes to regulate the physiological and pathophysiological outcomes of oxidant exposure. This review discusses the impact of Nrf2 on oxidative stress and toxicity and how Nrf2 senses oxidants and regulates antioxidant defense.

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          Author and article information

          Journal
          Annu Rev Pharmacol Toxicol
          Annual review of pharmacology and toxicology
          Annual Reviews
          1545-4304
          0362-1642
          2013
          : 53
          Affiliations
          [1 ] Receptor Biology Laboratory, Toxicology and Molecular Biology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention. qam1@cdc.gov
          Article
          NIHMS742707
          10.1146/annurev-pharmtox-011112-140320
          4680839
          23294312
          8d812682-fc0c-4b50-883b-805a15bd95a8
          History

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