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      Magnetic resonance spectroscopy may serve as a presurgical predictor of somatostatin analog therapy response in patients with growth hormone-secreting pituitary macroadenomas.

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          Abstract

          Somatostatin analogs (SSAs) are considered one of the most effective medical treatments for patients with growth hormone-secreting pituitary adenomas (GH-PAs). The postoperative electron microscopy (EM) pathological subtype and SSTR2 expression in the tumor are the most established predictors of patient response to SSA therapy. The aim of this study was to evaluate how will magnetic resonance spectroscopy (MRS) measurements before surgery predict the EM pathological subtypes and SSTR2 expression of tumors, and thereby serve as an indicator for the therapeutic sensitivity to SSAs of patients with GH-PAs.

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          Author and article information

          Journal
          J Endocrinol Invest
          Journal of endocrinological investigation
          Springer Science and Business Media LLC
          1720-8386
          0391-4097
          Apr 2019
          : 42
          : 4
          Affiliations
          [1 ] Multidisciplinary Center for Pituitary Adenomas of Chongqing, Chongqing, 400037, China.
          [2 ] Department of Neurosurgery, Xinqiao Hospital, Army Medical University, Chongqing, 400037, China.
          [3 ] Department of Radiology, Xinqiao Hospital, Army Medical University, Chongqing, 400037, China.
          [4 ] Department of Pathology, Xinqiao Hospital, Army Medical University, Chongqing, 400037, China.
          [5 ] Department of Endocrinology, Xinqiao Hospital, Army Medical University, Chongqing, 400037, China.
          [6 ] Department of Biology and Biochemistry, University of Houston, Houston, TX, USA.
          [7 ] Multidisciplinary Center for Pituitary Adenomas of Chongqing, Chongqing, 400037, China. huiyangxinqiao@163.com.
          [8 ] Department of Neurosurgery, Xinqiao Hospital, Army Medical University, Chongqing, 400037, China. huiyangxinqiao@163.com.
          [9 ] Multidisciplinary Center for Pituitary Adenomas of Chongqing, Chongqing, 400037, China. dlisong3@163.com.
          [10 ] Department of Neurosurgery, Xinqiao Hospital, Army Medical University, Chongqing, 400037, China. dlisong3@163.com.
          Article
          10.1007/s40618-018-0939-4
          10.1007/s40618-018-0939-4
          30171531
          8d8145a8-4895-4b9b-bce7-957025550b20
          History

          Granulation,Growth hormone-secreting pituitary adenomas,Proton magnetic resonance spectroscopic imaging,Somatostatin receptor subtype 2

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