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      Small silencing RNAs: an expanding universe.

      Nature reviews. Genetics

      Gene Expression Regulation, genetics, MicroRNAs, Models, Genetic, RNA Interference, RNA, Small Interfering, RNA-Induced Silencing Complex

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          Abstract

          Since the discovery in 1993 of the first small silencing RNA, a dizzying number of small RNA classes have been identified, including microRNAs (miRNAs), small interfering RNAs (siRNAs) and Piwi-interacting RNAs (piRNAs). These classes differ in their biogenesis, their modes of target regulation and in the biological pathways they regulate. There is a growing realization that, despite their differences, these distinct small RNA pathways are interconnected, and that small RNA pathways compete and collaborate as they regulate genes and protect the genome from external and internal threats.

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          Journal
          19148191
          2724769
          10.1038/nrg2504

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