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      Confirmatory interleukin-1 receptor antagonist trial in severe sepsis : A phase III, randomized, doubleblind, placebo-controlled, multicenter trial

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          Most cited references23

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          Interleukin-1 receptor antagonist activity of a human interleukin-1 inhibitor.

          Three interleukin-1 inhibitors have been purified to homogeneity from medium conditioned by human monocytes. Partial sequence analysis and digestion with N-glycanase indicate that these are glycosylation forms of a single protein. The protein binds to the interleukin-1 receptor but has no interleukin-1-like activity, even at very high concentrations, and is therefore a pure receptor antagonist.
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            Primary structure and functional expression from complementary DNA of a human interleukin-1 receptor antagonist.

            Human monocytes induced with adherent IgG secrete an interleukin-1 receptor antagonist which could be important for the in vivo regulation of IL-1 activity. A complementary DNA for this molecule has been isolated from a human monocyte library. Analysis of monocyte RNA indicates that the gene is transcriptionally regulated. The sequence of the receptor antagonist indicates that it is structurally similar to IL-1 beta. Expression of the cDNA in Escherichia coli yields IL-1 receptor antagonist activity.
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              Recombinant Human Interleukin 1 Receptor Antagonist in the Treatment of Patients With Sepsis Syndrome

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                Author and article information

                Journal
                Critical Care Medicine
                Critical Care Medicine
                Ovid Technologies (Wolters Kluwer Health)
                0090-3493
                1997
                July 1997
                : 25
                : 7
                : 1115-1124
                Article
                10.1097/00003246-199707000-00010
                9233735
                8db3cf2d-4d8f-459f-9df2-3b3810375889
                © 1997
                History

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