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      Bacterial Populations of the Small Intestine in Uremia

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          Abstract

          The small intestinal bacterial flora of 15 patients with chronic renal insufficiency was compared with that of subjects with blind loop syndrome. 9 patients were on regular hemodialysis with high protein intake and 6 (serum creatinine 7.5 to 12.5 mg/dl) were maintained on low protein diet. The chronic renal patients harbored a greatly increased microbial flora of both anaerobes and aerobes in the duodenum and jejunum, quantitatively comparable to those in blind loop subjects. The composition did not differ significantly in the two groups. Some organisms may have the potential to metabolize substrates which reach the intestinal lumen from the diet and bile, and perhaps to generate toxic metabolites that could contribute to uremic toxicity or malabsorption.

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          Author and article information

          Journal
          NEF
          Nephron
          10.1159/issn.1660-8151
          Nephron
          S. Karger AG
          978-3-8055-2981-5
          978-3-318-02025-0
          1660-8151
          2235-3186
          1978
          1978
          02 December 2008
          : 22
          : 1-3
          : 63-68
          Affiliations
          Division of Nephrology and Gastroenterology, Departments of Medicine and Microbiology, Jefferson Medical College of Thomas Jefferson University, Philadelphia, Pa.
          Article
          181424 Nephron 1978;22:63–68
          10.1159/000181424
          745639
          © 1978 S. Karger AG, Basel

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          Page count
          Pages: 6
          Categories
          Original Paper

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