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      Lactobacillus rhamnosus induced epithelial cell apoptosis, ameliorates inflammation and prevents colon cancer development in an animal model.

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          Abstract

          Probiotics have been suggested as prophylactic measure in colon carcinogenesis. This study aimed at determining the potential prophylactic activity of Lactobacillus rhamnosus GG CGMCC 1.2134 (LGG) strain on colorectal carcinogenesis via measuring its effect on Nuclear factor kappa B (NFκB) inflammatory pathway and apoptosis.

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          Author and article information

          Journal
          Biomed. Pharmacother.
          Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
          Elsevier BV
          1950-6007
          0753-3322
          Oct 2016
          : 83
          Affiliations
          [1 ] Department of Biochemistry and Molecular Biology, Dalian Medical University, Dalian 116044, China.
          [2 ] Department of Pathology and Pathophysiology, Dalian Medical University, Dalian 116044, China.
          [3 ] Department of Acute abdominal Surgery, Second Affiliated Hospital of Dalian Medical University, China. Electronic address: fuwenluo@aliyun.com.
          [4 ] Department of Biochemistry and Molecular Biology, Dalian Medical University, Dalian 116044, China. Electronic address: jimxin@hotmail.com.
          Article
          S0753-3322(16)30582-0
          10.1016/j.biopha.2016.07.001
          27447122
          8dc1a6fb-d5d7-47d2-a18e-7f5d483b6cb9
          History

          Colon cancer,Lactobacillus,Apoptosis,Inflammation
          Colon cancer, Lactobacillus, Apoptosis, Inflammation

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