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      Renal Tubular Secretion of P-Aminohippurate in the Dog: Effects of Alpha-Ketoglutarate

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      Nephron

      S. Karger AG

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          Abstract

          Several organic acids depress renal transport of p-aminohippurate (PAH). In most instances, the effects can be ascribed to competitive inhibition of PAH transport. However, the nature of the depression of PAH secretion produced by dicarboxylic acids of the Krebs cycle has not been elucidated. In studies performed on dogs, using renal clearance and extraction procedures, we found that inhibition of PAH secretion induced by α-ketoglutarate (α-KG) occurs at all tubular loads of PAH, below and above Tm. The degree of inhibition of Tmpah is proportional to the renal loads of α-KG. Furthermore, depression of PAH transport induced by α-KG is sustained, i.e. it is not readily overcome by increasing PAH levels. Administration of acetate, which in normal conditions produces striking enhancement of PAH secretion, has no effect when given simultaneously with α-KG. We conclude that inhibition is noncompetitive or mixed and that renal metabolic activity is an important factor influencing PAH secretion.

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          Author and article information

          Journal
          NEF
          Nephron
          10.1159/issn.1660-8151
          Nephron
          S. Karger AG
          1660-8151
          2235-3186
          1969
          1969
          26 November 2008
          : 6
          : 6
          : 633-642
          Affiliations
          Department of Physiology, Cornell University Medical College, New York, NY
          Article
          179764 Nephron 1969;6:633–642
          10.1159/000179764
          5372422
          © 1969 S. Karger AG, Basel

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          Page count
          Pages: 10
          Categories
          Paper

          Cardiovascular Medicine, Nephrology

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