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      Quantitative Assessment ofCoronary Arteriosclerosis in Hypertensive Rats

      Cardiology

      S. Karger AG

      Arteriosclerosis, coronary, Hypertension, Rat, Skelton, Quantitative assessment

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          Abstract

          Following Skelton’s procedure with unilateral adrenonephrectomy, contralateral adrenal enucleation and application of 1 % NaCl with the drinking fluid, genetically normotensive rats develop hypertension and a generalized arteriosclerosis, i.e. necrotizing hypertensive angiopathy. In the present study, the effect of high blood pressure was investigated in 13 Skelton hypertensive rats and 13 normotensive control rats. Systolic blood pressure was investigated by tail plethysmography over a period of 7 weeks. During the experiments, 3 of the Skelton rats died with final high blood pressure values, whereas all controls remained alive. Mean systolic blood pressure of the 10 surviving Skelton rats increased from 108 to 223 mm Hg. The control rats remained normotensive. Accordingly, heart weights of the hypertensives were higher than those of the controls (p = 0.0027). At the end of the experiment, arteriosclerosis was quantified by counting the heart arteries and arterioles with deposits of fibrinoid in the vascular wall in 10 histological cross-sections per heart. In the right ventricular wall of 6 of the 10 surviving Skelton rats, arteries and arterioles with deposits of fibrinoid in the vascular wall were detected. No such alteration was observed in the left ventricular wall or in the interventricular septum. About one third of the altered blood vessels showed fibrinoid necrosis. In contrast, the normotensive control rats had neither fibrinoid necrosis nor sclerotic arteries in corresponding sections of the hearts (p = 0.0052). The findings show that Skelton hypertension can be used as an experimental model for quantitative histological investigation of coronary arteriosclerosis in hypertensive rats. It has to be carified why coronary arteriosclerosis only develops in the right and not in the left ventricular wall or in the interventricular myocardium, and why coronary arteriosclerosis is not obligatory in all hypertensive rats.

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          Author and article information

          Journal
          CRD
          Cardiology
          10.1159/issn.0008-6312
          Cardiology
          S. Karger AG
          0008-6312
          1421-9751
          1995
          1995
          19 November 2008
          : 86
          : 3
          : 224-231
          Affiliations
          Institute of Anatomy, University of Bonn, Germany
          Article
          176878 Cardiology 1995;86:224–231
          10.1159/000176878
          7614495
          © 1995 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          Page count
          Pages: 8
          Categories
          General Cardiology, Basic Research

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